Driven by the recent experimental hints of lepton-flavor-universality violation in the bottom-quark sector, we consider a simple extension of the Standard Model (SM) with an additional vector leptoquark $V_{\rm LQ}({\bf 3},{\bf 1},2/3)S_{\rm DQ}({\bf 6},{\bf 1},4/3)$ under the SM gauge group , in order to simultaneously explain the (with ) and $b \to c l^- \bar \nu_ll=e,\mu,\tau$) flavor anomalies, as well as to generate small neutrino masses through a two-loop radiative mechanism. We perform a global fit to all the relevant and up-to-date and data under the assumption that the leptoquark couples predominantly to second and third-generation SM fermions. We then look over the implications of the allowed parameter space on lepton-flavor-violating and decay modes, such as $B_s \to l^+_i l^-_j, \ B \to K^{(*)} l^+_i l^-_j, \ B_s \to \phi l^+_i l^-_j\Upsilon(nS) \to \mu \tau\tau \to \mu \gamma\tau \to \mu \phi (\eta^{(\prime)})$, respectively. Minimally extending this model by adding a fermion singlet also explains the ANITA anomalous upgoing events. Furthermore, we provide complementary constraints on leptoquark and diquark couplings from high-energy collider and other low-energy experiments to test this model.

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