Let be self-adjoint and let (playing the role of the annihilator operator) be -bounded. Assuming some additional hypotheses on (so that the creation operator is a singular perturbation of ), by a twofold application of a resolvent Krein-type formula, we build self-adjoint realizations of the formal Hamiltonian with . We give an explicit characterization of and provide a formula for the resolvent difference . Moreover, we consider the problem of the description of as a (norm resolvent) limit of sequences of the kind , where the 's are regularized operators approximating and the 's are suitable renormalizing bounded operators. These results show the connection between the construction of singular perturbations of self-adjoint operators by Krein’s resolvent formula and nonperturbative theory of renormalizable models in Quantum Field Theory; in particular, as an explicit example, we consider the Nelson model.

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