We study the global approximate controllability of the reaction-diffusion equation in a parallelpiped $ \Omega = (a_1,b_1 ) \times \ldots (a_n,b_n) \subset R^n $, governed by a multiplicative control in a reaction term. It is assumed that the initial state admits zeros only on the intersections of with finitely many hyperplanes, parallel to the sides of , and that changes its sign after crossing such hyperplanes (we further refer to them as the “hyperplanes of change of sign” or “zero hyperplanes”). This paper can be viewed as a continuation of work presented in \cite{CanKh, CanKh2} for the controllability of the one dimensional reaction-diffusion equation with solutions admitting finitely many zeros. However, the methods of \cite{CanKh, CanKh2} are intrinsically one dimensional, while in this paper we introduce a novel approach to deal with the case of multiple spatial variables.

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