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In this paper, we establish various maximal principles and develop the direct moving planes and sliding methods for equations involving the physically interesting (nonlocal) pseudo-relativistic Schr"{o}dinger operators with and mass . As a consequence, we also derive multiple applications of these direct methods. For instance, we prove monotonicity, symmetry and uniqueness results for solutions to various equations involving the operators in bounded domains, epigraph or , including pseudo-relativistic Schr"odinger equations, 3D boson star equations and the equations with De Giorgi type nonlinearities.

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