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A system of Boundary-Domain Integral Equations is derived from the mixed (Dirichlet-Neumann) boundary value problem for the diffusion equation in inhomogeneous media defined on an unbounded domain. Boundary-domain integral equations are formulated in terms of parametrix-based potential type integral operators defined on the boundary and the domain. Mapping properties of parametrix-based potentials on weighted Sobolev spaces are analysed. Equivalence between the original boundary value problem and the system of BDIEs is shown. Uniqueness of solution of the BDIEs is proved using Fredholm Alternative and compactness arguments adapted to weigthed Sobolev spaces.

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