We consider the chemotaxis-Navier-Stokes system with generalized fluid dissipation in : \begin{eqnarray*} \begin{cases} \partial_t n+u\cdot \nabla n=Δn- \nabla \cdot (χ©n \nabla c),\ \partial_t c+u \cdot \nabla c=Δc-nf©,\ \partial_t u +u \cdot \nabla u+\nabla P=-(-Δ)^αu-n\nabla φ,\ \nabla \cdot u=0, \end{cases} \end{eqnarray*} which describes the motion of swimming bacteria or bacillus subtilis suspended to water flows. First, we prove some blow-up criteria of strong solutions to the Cauchy problem, including the Prodi-Serrin type criterion () and the Beiro da Veiga type criterion . Then, we verify the global existence and uniqueness of strong solutions for arbitrarily large initial fluid velocity and bacteria density for . Furthermore, in the scenario of , we establish uniform regularity estimates and optimal time-decay rates of global solutions if the -norm of initial data is small. To our knowledge, this is the first result concerning the global existence and large-time behavior of strong solutions for the chemotaxis-Navier-Stokes equations with possibly large oscillations.

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