In this paper, we mainly consider the relative isoperimetric inequalities for minimal submanifolds with free boundary. We first generalize ideas of restricted normal cones introduced by Choe-Ghomi-Ritor'e in \cite{CGR06} and obtain an optimal area estimate for generalized restricted normal cones. This area estimate, together with the ABP method of Cabr'e in \cite{Cabre2008}, provides a new proof of the relative isoperimetric inequality obtained by Choe-Ghomi-Ritor'e in \cite{CGR07}. Furthermore, we use this estimate and the idea of Brendle in his recent work \cite{Brendle2019} to obtain a relative isoperimetric inequality for minimal submanifolds with free boundary on a convex support surface in , which is optimal and gives an affirmative answer to an open problem proposed by Choe in \cite{Choe2005}, Open Problem 12.6, when the codimension .

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