Weighted Hardy-Rellich type inequalities: improved best constants and symmetry breaking

When studying the weighted Hardy-Rellich inequality in $L^2$ with the full gradient replaced by the radial derivative the best constant becomes trivially larger or equal than in the first situation. Our contribution is to determine the new sharp constant and to show that for some part of the weights is strictly larger than before. In some cases we emphasize that the extremals functions of the sharp constant are not radially symmetric.