Recently, Huang showed that every -vertex induced subgraph of the -dimensional hypercube has maximum degree at least in [Annals of Mathematics, 190 (2019), 949–955]. In this paper, we discuss the induced subgraphs of Cartesian product graphs and semi-strong product graphs to generalize Huang’s result. Let be a connected signed bipartite graph of order and be a connected signed graph of order . By defining two kinds of signed product of and , denoted by and , we show that if and have exactly two distinct adjacency eigenvalues and respectively, then every -vertex induced subgraph of (resp. $\Gamma_1\widetilde{\bowtie} \Gamma_2\sqrt{\theta_1^2+\theta_2^2}\sqrt{(\theta_1^2+1)\theta_2^2}\Gamma_1\widetilde{\Box} \Gamma_2\Gamma_1\widetilde{\bowtie} \Gamma_2\Gamma_1\widetilde{\Box}\Gamma_2\Gamma_1\widetilde{\bowtie}\Gamma_2$ are symmetric, from which we obtain more general results on maximum degree of the induced subgraphs.

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