Unsupervised Online Feature Selection for Cost-Sensitive Medical Diagnosis

In medical diagnosis, physicians predict the state of a patient by checking measurements (features) obtained from a sequence of tests, e.g., blood test, urine test, followed by invasive tests. As tests are often costly, one would like to obtain only those features (tests) that can establish the presence or absence of the state conclusively. Another aspect of medical diagnosis is that we are often faced with unsupervised prediction tasks as the true state of the patients may not be known. Motivated by such medical diagnosis problems, we consider a {\it Cost-Sensitive Medical Diagnosis} (CSMD) problem, where the true state of patients is unknown. We formulate the CSMD problem as a feature selection problem where each test gives a feature that can be used in a prediction model. Our objective is to learn strategies for selecting the features that give the best trade-off between accuracy and costs. We exploit the Weak Dominance' property of problem to develop online algorithms that identify a set of features which provides an optimal’ trade-off between cost and accuracy of prediction without requiring to know the true state of the medical condition. Our empirical results validate the performance of our algorithms on problem instances generated from real-world datasets.