We formulate a strategy for computing the complete set of non-perturbative corrections to closed string scattering in string theory from the worldsheet perspective. This requires taking into account the effect of multiple ZZ-instantons, including higher instantons constructed from ZZ boundary conditions of type , with a careful treatment of the measure and contour in the integration over the instanton moduli space. The only a priori ambiguity in our prescription is a normalization constant that appears in the integration measure for the -type ZZ instanton, at each positive integer . We investigate leading corrections to the closed string reflection amplitude at the -instanton level, i.e. of order , and find striking agreement with our recent proposal on the non-perturbative completion of the dual matrix quantum mechanics, which in turn fixes for all .

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