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Nuclear medium effects on B meson production are studied using the binary-collision scaled cross section ratio between events of different charged-particle multiplicities from proton-lead collisions. Data, collected by the CMS experiment in 2016 at a nucleon-nucleon center-of-mass energy of = 8.16 TeV, corresponding to an integrated luminosity of 175 nb, were used. The scaling factors in the ratio are determined using a novel approach based on the Z cross sections measured in the same events. The scaled ratio for B is consistent with unity for all event multiplicities, putting stringent constraints on nuclear modification for heavy flavor.

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