Given an Azumaya algebra with involution over a commutative ring and some auxiliary data, we construct an -periodic chain complex involving the Witt groups of and other algebras with involution, and prove it is exact when is semilocal. When is a field, this recovers an -periodic exact sequence of Witt groups of Grenier-Boley and Mahmoudi, which in turn generalizes exact sequences of Parimala–Sridharan–Suresh and Lewis. We apply this result in several ways: We establish the Grothendieck–Serre conjecture on principal homogeneous bundles and the local purity conjecture for certain outer forms of and , provided some assumptions on . We show that a -hermitian form over a quadratic 'etale or quaternion Azumaya algebra over a semilocal ring is isotropic if and only if its trace (a quadratic form over ) is isotropic, generalizing a result of Jacobson. We also apply it to characterize the kernel of the restriction map when is a (non-semilocal) -dimensional regular domain and is a quadratic 'etale -algebra, generalizing a theorem of Pfister. In the process, we establish many fundamental results concerning Azumaya algebras with involution and hermitian forms over them.

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