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For a given smooth -knot in , we relate the existence of a smooth Seifert hypersurface of a certain class to the existence of irreducible -representations of its knot group. For example, we see that any smooth -knot having the Poincar'e homology -sphere as a Seifert hypersurface has at least four irreducible -representations of its knot group. This result is false in the topological category. The proof uses a quantitative formulation of instanton Floer homology. Using similar techniques, we also obtain similar results about codimension- embeddings of homology -spheres into closed definite -manifolds and a fixed point type theorem for instanton Floer homology.

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