We study the generalized Hartree equation, which is a nonlinear Schr"odinger-type equation with a nonlocal potential $iu_t + \Delta u + (|x|^{-b} \ast |u|^p)|u|^{p-2}u=0, x \in ^N$.We establish the local well-posedness at the non-conserved critical regularity for , which also includes the energy-supercritical regime (thus, complementing the work in [3], where the authors obtained the well-posedness in the intercritical regime together with classification of solutions under the mass-energy threshold). We next extend the local theory to global: for small data we obtain global in time existence and for initial data with positive energy and certain size of variance we show the finite time blow-up (blow-up criterion). Both of these results hold regardless of the criticality of the equation. In the intercritical setting the criterion produces blow-up solutions with the initial values above the mass-energy threshold. We conclude with examples showing currently known thresholds for global vs. finite time behavior.

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