processes are unique probes of flavor physics in the up-sector within and beyond the Standard Model (SM). SM tests with rare semileptonic charm meson decays are based on an approximate CP–symmetry, a superior GIM–mechanism, angular distributions, lepton-universality and lepton flavor conservation. We analyze the complete set of null test observables in $D \to \pi \ell \ell^{(\prime)}D_s \to K \ell \ell^{(\prime)}\ell^{(\prime)}=e, \mu$, and find large room for new physics safely above the SM contribution. We identify signatures of supersymmetry, leptoquarks and anomaly-free -models with generation-dependent charges, for which we provide explicit examples. -effects in $c \to u \ell \ell^{(\prime)}$ transitions can be sizable if both left-handed and right-handed couplings to quarks are present.

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