We investigate the phenomenological impact of incorporating vector-like bottom (VLB) quarks into the Type-II Two-Higgs-Doublet Model (2HDM-II). This framework introduces novel beyond-Standard-Model (BSM) decay channels , , and , which are typically ignored by LHC pair-production searches focused on Standard Model (SM) final states (, , ). Our analysis reveals that these BSM pathways significantly weaken current VLB mass constraints. In the 2HDM-II alignment limit, the mass limit for a singlet shifts from approximately 1.5 TeV down to 1.34 TeV. For and doublet configurations, the mass limits relax further to approximately 0.98 TeV, driven by the dominance of and decays, which can reach combined branching ratios of nearly 100%.

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