The Drazin index is a fundamental invariant in the analysis of singular matrices and their generalized inverses. While sharp results are available for block triangular matrices, the corresponding theory for anti-triangular block matrices is less developed. In this paper, we study matrices of the form under algebraic constraints on the blocks. Building on additive decompositions involving von Neumann inverses, we relate the Drazin index of to invariance properties of the index and minimal polynomial of expressions of the form . This connection provides an effective mechanism to control the index of through suitable factorizations and associated block products. As a consequence, we derive explicit lower and upper bounds for in terms of and , and characterize situations in which these bounds are attained. Under additional annihilation or orthogonality conditions on the blocks, we obtain closed-form representations for the Drazin inverse of . Applications to adjacency matrices of directed graphs illustrate the sharpness of the bounds and the applicability of the results to structured matrices arising in graph-theoretic settings.

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