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We consider anti-phase synchronization of coupled oscillators using the Stuart-Landau model and explore its relative infrequency in occurrence compared to in-phase synchronization. We report effective limits in number of oscillators which can anti-phase synchronize for general configurations of real-world networks. We link anti-phase synchronization to the Ising model and consequently to combinatorial optimization problems, thereby explaining experimentally observed limits in self-organization of natural systems. We illustrate this using the Steiner-tree problem.

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