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We study constraints on dimension-7 SMEFT baryon-number-violating operators from nucleon decays by incorporating full renormalization group (RG) running effects. At high new physics scales, we demonstrate that RG running effects help set stringent bounds on all 297 Wilson coefficients compared to the tree-level analysis in which only coefficients involving the first and second fermion generations could be constrained. Our findings highlight that the RG running effects through Yukawa mixings are particularly important for indirectly probing operators involving the second and third generation fermions.

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