Einstein's biggest mistake?

What, if any, was Einstein’s biggest mistake, the one most affecting our physics today? There is a perhaps apocryphal story, recounted by George Gamow, that he counted his cosmological constant as his biggest blunder. We now know his hypothesized cosmological constant to be correct. His lifelong rejection of quantum mechanics, an interesting side-story in the evolution of 20th-century physics, is a candidate. None of these introduced difficulties in how our physics is done today. It can be argued that his biggest actual mistake, one that affects many subfields of physics and chemistry and bewilders students today, occurred in his naming of his A and B coefficients.