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We consider the Cauchy problem associated to the fourth-order nonlinear Schr"{o}dinger-Hartree equation with variable dispersion coefficients. The variable dispersion coefficients are assumed to be continuous or periodic and piecewise constant in time functions. We prove local and global well-posedness results for initial data in -spaces. We also analyze the scaling limit of fast dispersion management and the convergence to a model with averaged dispersions.

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