In this paper, we are concerned with equations \eqref{PDE} involving higher-order fractional Laplacians. By introducing a new approach, we prove the super poly-harmonic properties for nonnegative solutions to \eqref{PDE} (Theorem \ref{Thm0}). Our theorem seems to be the first result on this problem. As a consequence, we derive many important applications of the super poly-harmonic properties. For instance, we establish Liouville theorems, integral representation formula and classification results for nonnegative solutions to fractional higher-order equations \eqref{PDE} with general nonlinearities including conformally invariant and odd order cases. In particular, our results completely improve the classification results for third order equations in Dai and Qin \cite{DQ1} by removing the assumptions on integrability. We also derive a characterization for -harmonic functions via averages in the appendix.

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