We present comprehensive observations and analysis of the energetic H-stripped SN 2016coi (a.k.a. ASASSN-16fp), spanning the -ray through optical and radio wavelengths, acquired within the first hours to 420 days post explosion. Our campaign confirms the identification of He in the SN ejecta, which we interpret to be caused by a larger mixing of Ni into the outer ejecta layers. From the modeling of the broad bolometric light curve we derive a large ejecta mass to kinetic energy ratio ($M_{\rm{ej}}\sim 4-7,\rm{M_{\odot}}E_{\rm{k}}\sim 7-8\times 10^{51},\rm{erg}$). The small [\ion{Ca}{ii}] \lam\lam7291,7324 to [\ion{O}{i}] \lam\lam6300,6364 ratio (0.2) observed in our late-time optical spectra is suggestive of a large progenitor core mass at the time of collapse. We find that SN 2016coi is a luminous source of X-rays ( in the first days post explosion) and radio emission ($L_{8.5,GHz}\sim7\times 10^{27},\rm{erg,s^{-1}Hz^{-1}}$ at peak). These values are in line with those of relativistic SNe (2009bb, 2012ap). However, for SN 2016coi we infer substantial pre-explosion progenitor mass-loss with rate $\dot M \sim (1-2)\times 10^{-4},\rm{M_{\odot}yr^{-1}}$ and a sub-relativistic shock velocity , in stark contrast with relativistic SNe and similar to normal SNe. Finally, we find no evidence for a SN-associated shock breakout -ray pulse with energy . While we cannot exclude the presence of a companion in a binary system, taken together, our findings are consistent with a massive single star progenitor that experienced large mass loss in the years leading up to core-collapse, but was unable to achieve complete stripping of its outer layers before explosion.

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