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Spectroscopic transiting observations of the atmospheres of hot Jupiters around other stars, first with Hubble Space Telescope and then Spitzer, opened the door to compositional studies of exoplanets. The James Webb Space Telescope will provide such a profound improvement in signal-to-noise ratio that it will enable detailed analysis of molecular abundances, including but not limited to determining abundances of all the major carbon- and oxygen-bearing species in hot Jupiter atmospheres. This will allow determination of the carbon-to-oxygen ratio, an essential number for planet formation models and a motivating goal of the Juno mission currently around Jupiter

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