Let , where denotes the space of square integrable probability measures, and consider a Borel-measurable function . IIn this paper we develop Antithetic Monte Carlo estimator (A-MLMC) for , which achieves sharp error bound under mild regularity assumptions. The estimator takes as input the empirical laws $\mu^N = \frac1N \sum_{i=1}^{N}\delta_{X_i}(X_i)_{i=1}^N$ is a sequence of i.i.d samples from or b) is a system of interacting particles (diffusions) corresponding to a McKean-Vlasov stochastic differential equation (McKV-SDE). Each case requires a separate analysis. For a mean-field particle system, we also consider the empirical law induced by its Euler discretisation which gives a fully implementable algorithm. As by-products of our analysis, we establish a dimension-independent rate of uniform \textit{strong propagation of chaos}, as well as an estimate of the antithetic difference for i.i.d. random variables corresponding to general functionals defined on the space of probability measures.

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