The topology of cosmic reionization, the sizes, shapes, and connectivity of ionized bubbles is a primary observable of next-generation 21,cm experiments. We show that this topology is sensitive to the microphysics of dark matter. Self-interacting dark matter (SIDM), with cross-sections – motivated by small-scale structure anomalies, reduces halo gas binding energies and increases the duty cycle of ionizing-photon escape. At fixed global neutral fraction , this reshapes the source population from rare, very bright emitters to more numerous, moderate emitters, producing qualitatively different ionization morphology. We decompose the effect into two scale-dependent levers: a – emissivity-weighted bias shift at , and a factor – shot-noise suppression at –. A halo-by-halo semi-numerical simulation at resolution confirms a – increase in the Euler characteristic of the ionization field for , detected at across ten independent realizations. A blowout model connecting the binding-energy reduction to the duty cycle through the ISM column density distribution yields a detection threshold at –. The signal exceeds the CDM baryonic uncertainty band and is robust to the functional form of the emissivity parametrization. The signal persists even if gravitational heating offsets – of the blowout enhancement, and is not diluted by unresolved low-mass sources. Velocity-dependent SIDM produces a qualitatively distinct opposite-sign bias shift. These predictions are testable with SKA1-Low, establishing reionization as a new arena for probing dark matter models complementary to dwarf galaxies and galaxy clusters.

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