We formulate the generalized Sarnak’s M"obius disjointness conjecture for an arbitrary number field , and prove a quantitative disjointness result between polynomial nilsequences and aperiodic multiplicative functions on , the ring of integers of . Here , is a nilmanifold, is a polynomial sequence, and $\Phi\colon X\to $ is a Lipschitz function. The proof uses tools from multi-dimensional higher order Fourier analysis, multi-linear analysis, orbit properties on nilmanifold, and an orthogonality criterion of K'atai in . We also use variations of this result to derive applications in number theory and combinatorics: (1) we prove a structure theorem for multiplicative functions on , saying that every bounded multiplicative function can be decomposed into the sum of an almost periodic function (the structural part) and a function with small Gowers uniformity norm of any degree (the uniform part); (2) we give a necessary and sufficient condition for the Gowers norms of a bounded multiplicative function in to be zero; (3) we provide partition regularity results over for a large class of homogeneous equations in three variables. For example, for , we show that for every partition of into finitely many cells, where , there exist distinct and non-zero belonging to the same cell and such that .

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