We report on OVRO, WISE, Swift and Fermi-LAT observations of the high redshift blazar CGRaBS J0733+0456, from which significant flux variations in radio, infrared (IR) as well as -ray domains are detected. Particularly, the amplitude of long-term IR variation is over one order of magnitude and the IR variability timescale can be constrained as short as a few hours in the source frame. The IR and -ray light curves are found to be rather similar, and the strong quasi-simultaneous infrared and -ray flares are proved to be unique among the nearby -ray sources. This is the first time to identify a ray blazar at redshift with multi-wavelength flux variations (flares). Broadband spectral energy distributions in different flux states are constructed and theoretically described. The ray flares from some blazars as distant as redshift 5 are expected to be detectable for Fermi-LAT.

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