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We construct the QCD equation of state at finite chemical potentials including net baryon, electric charge, and strangeness, based on the conserved charge susceptibilities determined from lattice QCD simulations and the equation of state of the hadron resonance gas model. For the application to relativistic heavy ion collisions we consider the situation of strangeness neutrality and matter with a fixed electric charge-to-baryon ratio, resembling that of heavy nuclei. The importance of finite electric charge and strangeness chemical potentials for particle production in heavy ion collisions is demonstrated using hydrodynamic simulations.

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