In this work, we present a scalable Linear Matrix Inequality (LMI) based framework to verify the stability of a set of linear Partial Differential Equations (PDEs) in one spatial dimension coupled with a set of Ordinary Differential Equations (ODEs) via input-output based interconnection. Our approach extends the newly developed state space representation and stability analysis of coupled PDEs that allows parametrizing the Lyapunov function on with multipliers and integral operators using polynomial kernels of semi-separable class. In particular, under arbitrary well-posed boundary conditions, we define the linear operator inequalities on $^n \times L_2$ and cast the stability condition as a feasibility problem constrained by LMIs. In this framework, no discretization or approximation is required to verify the stability conditions of PDE-ODE coupled systems. The developed algorithm has been implemented in MATLAB where the stability of example PDE-ODE coupled systems are verified.

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