The unification of quantum mechanics and general relativity remains among the most profound challenges in fundamental physics. Here we investigate a novel quantum probe of strong-field gravity: the gravitomagnetic Aharonov-Bohm (AB) effect for Cooper pairs propagating in Kerr spacetime. The frame-dragging induced by a rotating black hole (BH) generates an effective vector potential through the off-diagonal metric component , which couples to the macroscopic phase of the superconducting condensate. We derive the gauge-invariant AB phase shift for an interferometer with arms at radii and , where is the Cooper pair mass and is the BH spin parameter. Remarkably, the predicted phases reach radians for Sgr~A* and radians for M87*, reflecting the enormous gravitomagnetic flux near supermassive BHs. We analyze the dependence on interferometer geometry, demonstrate that tidal disruption of Cooper pairs is negligible at distances , and establish connections to the geometric Berry phase. Although direct experimental realization remains beyond current technology due to the vast distances involved, our framework provides quantitative predictions linking quantum coherence to spacetime curvature, complementing recent observations of gravitational AB phases in atom interferometry.

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