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In this article we consider the approximation of a variable coefficient (two-sided) fractional diffusion equation (FDE), having unknown . By introducing an intermediate unknown, , the variable coefficient FDE is rewritten as a lower order, constant coefficient FDE. A spectral approximation scheme, using Jacobi polynomials, is presented for the approximation of , . The approximate solution to , , is obtained by post processing . An a priori error analysis is given for and . Two numerical experiments are presented whose results demonstrate the sharpness of the derived error estimates.

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