We investigate Majorana dark matter in a new variant of gauge extension of Standard Model, where the scalar sector is enriched with an inert doublet and a scalar leptoquark. We compute the WIMP-nucleon cross section in leptoquark portal and the relic density mediated by inert doublet components, leptoquark and the new boson. We constrain the parameter space consistent with Planck limit on relic density, PICO-60 and LUX bounds on spin-dependent direct detection cross section. Furthermore, we constrain the new couplings from the present experimental data on , , , ${\rm Br}(B^+ \to K^+ \tau^+ \tau^-)B_s-\bar{B_s}$ mixing, which occur at one-loop level in the presence of and leptoquark. Using the allowed parameter space, we estimate the form factor independent observables and the lepton non-universality parameters , and . We also briefly discuss about the neutrino mass generation at one-loop level and the viable parameter region to explain current neutrino oscillation data.

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