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We show that every positive definite closed 4-manifold with and without 1-handles has a vanishing stable cohomotopy Seiberg-Witten invariant, and thus admits no symplectic structure. We also show that every closed oriented 4-manifold with and and without 1-handles admits no symplectic structure for at least one orientation of the manifold. In fact, relaxing the 1-handle condition, we prove these results under more general conditions which are much easier to verify.

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