Given two random variables and , an operational approach is undertaken to quantify the ``leakage’’ of information from to . The resulting measure is called \emph{maximal leakage}, and is defined as the multiplicative increase, upon observing , of the probability of correctly guessing a randomized function of , maximized over all such randomized functions. A closed-form expression for $(X !! \to !! Y)XY$, and it is subsequently generalized to handle a large class of random variables. The resulting properties are shown to be consistent with an axiomatic view of a leakage measure, and the definition is shown to be robust to variations in the setup. Moreover, a variant of the Shannon cipher system is studied, in which performance of an encryption scheme is measured using maximal leakage. A single-letter characterization of the optimal limit of (normalized) maximal leakage is derived and asymptotically-optimal encryption schemes are demonstrated. Furthermore, the sample complexity of estimating maximal leakage from data is characterized up to subpolynomial factors. Finally, the \emph{guessing} framework used to define maximal leakage is used to give operational interpretations of commonly used leakage measures, such as Shannon capacity, maximal correlation, and local differential privacy.

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