Context. The evolution of massive star-forming clumps that are progenitors of high-mass young stellar objects are often classified based on a variety of observational indicators ranging from near-infrared to radio wavelengths. Among them, the ratio of the bolometric luminosity to the mass of their envelope, , has been observationally diagnosed as a good indicator for the evolutionary classification of parsec-scale star-forming clumps in the Galaxy. Aims. We developed the Rosetta Stone projectan end-to-end framework designed to enable an accurate comparison between simulations and observations for investigating the formation and evolution of massive clumps. In this study, we calibrate the indicator in relation to the star formation efficiency (SFE) and the clump age, as derived from our suite of simulations. Methods. We performed multi-wavelength radiative transfer post-processing of radiative magnetohydrodynamics (RMHD) simulations of the collapse of star-forming clumps fragmenting into protostars. We generated synthetic observations to obtain far-infrared emission from to m, as was done in the Hi-GAL survey, and at m in the MIPSGAL survey, which were then used to build the spectral energy distributions (SEDs) and estimate the parameter. An additional mm wavelength in ALMA Band 6 was also produced for the comparison with observational data. We applied observational techniquescommonly employed by observersto the synthetic data in order to derive the corresponding physical parameters. Results. We find a correlation between and the SFE, with a power-law form . This correlation is independent of the mass of the clumps and the choice of initial conditions of the simulations in which they formed. (Abridged)

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