Multimode cavity-QED systems can be leveraged to explore a wide range of physical phenomena; however, a complex multimode environment makes systematic characterization of light-matter interactions challenging. Here we present a general measurement protocol, applicable to both atomic and synthetic cavity-QED systems, that enables the determination of coupling to individual photonic modes. The method leverages measurements of the AC-Stark and Kerr effects, along with known detuning dependencies, to eliminate the need for single-photon resolution, independent photon-number calibration, or insertion-loss calibration. We demonstrate the method using a superconducting transmon qubit coupled to a one-dimensional microwave resonator lattice. We validate the consistency of the extracted light-matter couplings determined at multiple qubit detunings, and from the self-Kerr and cross-Kerr shifts for three photon modes, which provide separate measurements of for each of the three modes.

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