The necessary and sufficient conditions for a regular positive entire solution of the biharmonic equation: \begin{equation} \label{0.1} -\Delta^2 u=u^{-p} ;; \mbox{in }, ;; p>1 \end{equation} to be a radially symmetric solution are obtained via the moving plane method (MPM) of a system of equations. It is well-known that for any , \eqref{0.1} admits a unique minimal positive entire radial solution and a family of non-minimal positive entire radial solutions such that $u_a (0)={\underline u}_a (0)=au_a ® \geq {\underline u}_a ®r \in (0, \infty){\underline u}_a ®u_a ®r=\infty$ are also known. We will see in this paper that the asymptotic behaviors similar to those of and at can determine the radial symmetry of a general regular positive entire solution of \eqref{0.1}. The precisely asymptotic behaviors of $u (x)-\Delta u (x)|x|=\infty$ need to be established such that the moving-plane procedure can be started. We provide the necessary and sufficient conditions not only for a regular positive entire solution of \eqref{0.1} to be the minimal entire radial solution, but also for to be a non-minimal entire radial solution.

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