We study a priori estimates for a class of non-negative local weak solution to the weighted fast diffusion equation $u_t = |x|^{\gamma} \nabla\cdot (|x|^{-\beta} \nabla u^m)0 < m <1(0,T)\times{\mathbb R}^N|x|^{\gamma}|x|^{-\beta}\gamma < N\gamma -2 < \beta \leq \gamma(N-2)/N$ can be both degenerate and singular and need not belong to the class , a typical assumption for this kind of problems. This range of parameters is optimal for the validity of a class of Caffarelli-Kohn-Nirenberg inequalities, which play the role of the standard Sobolev inequalities in this more complicated weighted setting. The weights that we consider are not translation invariant and this causes a number of extra difficulties and a variety of scenarios: for instance, the scaling properties of the equation change when considering the problem around the origin or far from it. We therefore prove quantitative - with computable constants - upper and lower estimates for local weak solutions, focussing our attention where a change of geometry appears. Such estimates fairly combine into forms of Harnack inequalities of forward, backward and elliptic type. As a consequence, we obtain H"older continuity of the solutions, with a quantitative (even if non-optimal) exponent. Our results apply to a quite large variety of solutions and problems. The proof of the positivity estimates requires a new method and represents the main technical novelty of this paper. Our techniques are flexible and can be adapted to more general settings, for instance to a wider class of weights or to similar problems posed on Riemannian manifolds, possibly with unbounded curvature. In the linear case, , we also prove quantitative estimates, recovering known results in some cases and extending such results to a wider class of weights.

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