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In this paper, we study the control of the traffic-driven epidemic spreading by immunization strategy. We consider the random, degree-based and betweeness-based immunization strategies, respectively. It is found that the betweeness-based immunization strategy can most effectively prevent the outbreak of traffic-driven epidemic. Besides, we find that the critical number of immune nodes above which epidemic dies out is increased with the enhancement of the spreading rate and the packet-generation rate.

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