We study conditions that ensure uniqueness theorems of Cuntz-Krieger type for relative Cuntz-Pimsner algebras associated to a -correspondence over a -algebra . We give general sufficient conditions phrased in terms of a multivalued map acting on the spectrum of . When is of Type I we construct a directed graph dual to and prove a uniqueness theorem using this graph. When is liminal, we show that topological freeness of this graph is equivalent to the uniqueness property for , as well as to an algebraic condition, which we call -acyclicity of . As an application we improve the Fowler-Raeburn uniqueness theorem for the Toeplitz algebra . We give new simplicity criteria for . We generalize and enhance uniqueness results for relative quiver -algebras of Muhly and Tomforde. We also discuss applications to crossed products by endomorphisms.

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