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In this paper, we study Hankel determinants generated from a perturbed Laguerre weight function, Under the double scaling scheme, we give the uniform asymptotic approximations of Hankel determinants in terms of a solution of a third-order nonlinear differential equation, which is equivalent to a particular Painleve V equation. In fact, this Painleve V equation is equivalent to the general Painleve III equation. The asymptotic approximations of the leading coefficients and the recurrence coefficients for the corresponding orthogonal polynomials also involve the painleve V equation. The asymptotic analysis is based on our earlier results by using the Deift-Zhou nonlinear steepest descent method.

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