Let be a smooth bounded domain and let , and . We prove the existence of solution of the fast diffusion equation , , in ( respectively) which satisfies as for any and , when , , and the initial value satisfies ( respectively) for some constant and for $x\approx a_i\gamma_i>\frac{2}{1-m},\lambda_i>0i=1,2,\dots,i_0$. We also find the blow-up rate of such solutions near the blow-up points , and obtain the asymptotic large time behaviour of such singular solutions. More precisely we prove that if on (, respectively) for some constant and , then the singular solution converges locally uniformly on every compact subset of (or respectively) to infinity as . If on (, respectively) for some constant and satisfies $\lambda_i|x-a_i|^{-\gamma_i}\le u_0(x)\le \lambda_i’|x-a_i|^{-\gamma_i’}x\approx a_i\frac{2}{1-m}<\gamma_i\le\gamma_i’<\frac{n-2}{m}\lambda_i>0\lambda_i’>0i=1,2,\dots,i_0uC^2(K)$ for any compact subset of (or respectively) to a harmonic function as .

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