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In this paper, we develop a wave function renormalization scheme for models of non-relativistic quantum particles interacting with a quantized relativistic field, in the Hamiltonian formalism of quantum field theory. We construct the interacting Hamilton operator, in its ground state representation, for a large class of particle-field interactions; hereby addressing a number of open problems related to both ultraviolet and infrared singularities in the spin-boson and Nelson models, where the infinite wave function renormalization plays a fundamental role.

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