Let () be an open domain which is not necessarily bounded. The sharp constant and extremal functions to the following kind of double-variable inequalities for $(u,v)\in {\mathscr{D}}:=D_{0}^{1,2}(\Omega)\times D_{0}^{1,2}(\Omega)$ will be explored. Further results about the sharp constant with its extremal functions when is a general open domain will be involved. For this goal, we consider the following elliptic systems involving multiple Hardy-Sobolev critical exponents: where $s_1,s_2\in (0,2), \alpha>1,\beta>1, \lambda>0,\mu>0,\kappa\neq 0, \alpha+\beta\leq 2^(s_2)2^(s):=\frac{2(N-s)}{N-2}$ is the critical Hardy-Sobolev exponent. We mainly study the critical case (i.e., ) when is a cone (in particular, or ). We will establish a sequence of fundamental results including regularity, symmetry, existence and multiplicity, uniqueness and nonexistence, {\it etc.}

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