We present a series of near-infrared spectra of Nova Ophiuchus 2017 in the band that record the evolution of the first overtone CO emission in unprecedented detail. Starting from 11.7d after maximum, when CO is first detected at great strength, the spectra track the CO emission to +25.6d by which time it is found to have rapidly declined in strength by almost a factor of 35. The cause for the rapid destruction of CO is examined in the framework of different mechanisms for CO destruction viz. an increase in photoionizating flux, chemical pathways of destruction or destruction by energetic non-thermal particles created in shocks. From LTE modelling of the CO emission, the C/C ratio is determined to be 1.6 0.3. This is consistent with the expected value of this parameter from nucleosynthesis theory for a nova eruption occuring on a low mass ( 0.6 M) carbon-oxygen core white dwarf. The present C/C estimate constitutes one of the most secure estimates of this ratio in a classical nova.

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