We study a class of eight-supercharge little string theories (LSTs) on the world-volume of M5-branes with transverse space $^{1}\times (^2/_M)$. These M-brane configurations compactified on a circle are dual to D5-branes intersecting NS5-branes on as well as to F-theory compactified on a toric Calabi-Yau threefold . We argue that the K"ahler cone of admits three regions associated with weakly coupled quiver gauge theories of gauge groups and where . These provide low-energy descriptions of different LSTs. The duality between the first two gauge theories is well known and is a consequence of the S-duality between D5- and NS5-branes or the T-duality of the LSTs. The triality involving the third gauge theory is new and we demonstrate it using several examples. We also discuss implications of this triality for the W-algebras associated with the Alday-Gaiotto-Tachikawa dual theories.

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