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An edge set of a connected graph is called an anti-Kekul'e set if is connected and has no perfect matchings, where denotes the subgraph obtained by deleting all edges in from . The anti-Kekul'e number of a graph , denoted by , is the cardinality of a smallest anti-Kekul'e set of . It is NP-complete to find the smallest anti-Kekul'e set of a graph. In this paper, we show that the anti-Kekul'{e} number of a 2-connected cubic graph is either 3 or 4, and the anti-Kekul'{e} number of a connected cubic bipartite graph is always equal to 4. Furthermore, a polynomial time algorithm is given to find all smallest anti-Kekul'{e} sets of a connected cubic graph.

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