We present a new lattice determination of some of the parameters appearing both in the Operator Product Expansion (OPE) analysis of the inclusive semileptonic -meson decays and in the Heavy Quark Expansion (HQE) of the pseudoscalar (PS) and vector (V) heavy-light meson masses. We perform a lattice QCD (LQCD) computation of PS and V heavy-light meson masses for heavy-quark masses in the range from to . We employed the gauge configurations of the European Twisted Mass Collaboration (ETMC) at three values of the lattice spacing $a \simeq (0.062, 0.082, 0.089)M_\pi \simeq (210 - 450)$ MeV. The heavy-quark mass is simulated directly on the lattice up to $\simeq 3m_c^{\rm phys}m_b^{\rm phys}$ is performed using the ETMC ratio method and adopting the kinetic mass scheme. We obtain GeV ( GeV in the scheme). The lattice data are analyzed in terms of the HQE and the matrix elements of dimension-4 and dimension-5 operators are extracted with good precision, namely: GeV, $\mu_\pi^2 = 0.321 (32)^2\mu_G^2(m_b) = 0.253 (25)^2$. The data also allow for an estimate of the dimension-6 operator matrix elements.

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